Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they act …

… Alvarez-Zarate & TK van den Berg, unpublished data); furthermore, the treatment of mice (33),
rats (A. van der Goes & TK van den Berg, unpublished data), and cynomolgus monkeys (…

Mature tissue macrophages form a first line of defense to recognize and eliminate potential
pathogens; these specialized cells are capable of phagocytosis, degradation of self and …

The plasma membrane glycoprotein receptor CD163 is a member of the scavenger receptor
cystein-rich (SRCR) superfamily class B that is highly expressed on resident tissue …

Immune checkpoint inhibitors, including those targeting CTLA ‐4/B7 and the PD ‐1/ PD ‐L1
inhibitory pathways, are now available for clinical use in cancer patients, with other …

Liposomes can be used as vehicles for intracellular delivery of drugs into phagocytic cells.
Clodronate and propamidine, delivered into macrophages in this way, will kill these cells as a …

Monoclonal antibodies are among the most promising therapeutic agents for treating cancer.
Therapeutic cancer antibodies bind to tumor cells, turning them into targets for immune-…

Macrophages tightly control the production and clearance of red blood cells (RBC). During
steady state hematopoiesis, approximately 10 10 RBC are produced per hour within …

… van den Berg Timo K. van den Berg 2 Wim JE van Esch Wim JE van Esch 5 Taco W.
Kuijpers Taco W. Kuijpers 2 Diana … Ellen van der Schoot for critically reading the manuscript. …

CD47 on erythrocytes inhibits phagocytosis through interaction with the inhibitory immunoreceptor
SIRPα expressed by macrophages. Thus, the CD47-SIRPα interaction constitutes a …