Rolling of leukocytes on vascular endotheliai cells, an early event in inflammation, can be
reproduced in vitro on artificial lipid bilayers containing purified CD62, a seiectln also named …

Multiple protein families, each with a distinct function, provide the traffic signals for
leukocytes. The selectin family of adhesion molecules (Figure 2) has an N-terminal domain …

The adhesive interactions of cells with other cells and with the extracellular matrix are crucial
to all developmental processes, but have a central role in the functions of the immune …

The circulatory and migratory properties of white blood cells have evolved to allow efficient
surveillance of tissues for infectious pathogens and rapid accu ญ mulation at sites of injury …

Effective interaction between T cells and their targets requires that recognition of specific
antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-…

CHEMOKINES are chemotactic cytokines that activate and direct the migration of leukocytes
1,2 . There are two subfamilies, the CXC and the CC chemokines. We recently found that …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Cell adhesion molecules are thought to play an important role in guiding cell migration and
localization in the development of the embryo and in organogenesis. In the immune system, …

Integrins are important adhesion receptors in all Metazoa that transmit conformational change
bidirectionally across the membrane. Integrin α and β subunits form a head and two long …

Although critical for development, immunity, wound healing, and metastasis, integrins
represent one of the few classes of plasma membrane receptors for which the basic signaling …