[HTML][HTML] Evolution of genes and genomes on the Drosophila phylogeny

…, M Kellis, W Gelbart, VN Iyer, DA Pollard, TB Sackton… - Nature, 2007 - hal.science
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves
the precision and sensitivity of evolutionary inference, producing more robust results than …

Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species

…, J Romero-Severson, M Rosenberg, TB Sackton… - Science, 2010 - science.org
We report here genome sequences and comparative analyses of three closely related
parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important …

[HTML][HTML] A scan for positively selected genes in the genomes of humans and chimpanzees

…, AG Clark, S Glanowski, TB Sackton… - PLoS …, 2005 - journals.plos.org
Since the divergence of humans and chimpanzees about 5 million years ago, these species
have undergone a remarkable evolution with drastic divergence in anatomy and cognitive …

Dense sampling of bird diversity increases power of comparative genomics

…, R Bowman, N Chen, A Cloutier, TB Sackton… - Nature, 2020 - nature.com
Whole-genome sequencing projects are increasingly populating the tree of life and
characterizing biodiversity 1 , 2 , 3 – 4 . Sparse taxon sampling has previously been proposed to …

Dynamic evolution of the innate immune system in Drosophila

TB Sackton, BP Lazzaro, TA Schlenke, JD Evans… - Nature …, 2007 - nature.com
The availability of complete genome sequence from 12 Drosophila species presents the
opportunity to examine how natural selection has affected patterns of gene family evolution and …

[HTML][HTML] Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment

…, WR Reid, FD Rinkevich, HM Robertson, TB Sackton… - Genome biology, 2014 - Springer
Background Adult house flies, Musca domestica L., are mechanical vectors of more than 100
devastating diseases that have severe consequences for human and animal health. House …

[HTML][HTML] Natural selection constrains neutral diversity across a wide range of species

RB Corbett-Detig, DL Hartl, TB Sackton - PLoS biology, 2015 - journals.plos.org
The neutral theory of molecular evolution predicts that the amount of neutral polymorphisms
within a species will increase proportionally with the census population size (Nc). However, …

Evolution of protein-coding genes in Drosophila

AM Larracuente, TB Sackton, AJ Greenberg, A Wong… - Trends in Genetics, 2008 - cell.com
Several contributing factors have been implicated in evolutionary rate heterogeneity among
proteins, but their evolutionary mechanisms remain poorly characterized. The recently …

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

KL Sackton, N Dimova, X Zeng, W Tian, M Zhang… - Nature, 2014 - nature.com
Protein machines are multi-subunit protein complexes that orchestrate highly regulated
biochemical tasks. An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-…

Convergent regulatory evolution and loss of flight in paleognathous birds

TB Sackton, P Grayson, A Cloutier, Z Hu, JS Liu… - Science, 2019 - science.org
A core question in evolutionary biology is whether convergent phenotypic evolution is
driven by convergent molecular changes in proteins or regulatory regions. We combined …