User profiles for Timothy C. Cairns
Timothy C CairnsSenior Scientist, Technical University Berlin Verified email at tu-berlin.de Cited by 2510 |
[HTML][HTML] Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper
The EUROFUNG network is a virtual centre of multidisciplinary expertise in the field of
fungal biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …
fungal biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …
[HTML][HTML] How a fungus shapes biotechnology: 100 years of Aspergillus niger research
In 1917, a food chemist named James Currie made a promising discovery: any strain of the
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …
[HTML][HTML] The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis
M Bertuzzi, M Schrettl, L Alcazar-Fuoli, TC Cairns… - PLoS …, 2014 - journals.plos.org
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the
mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is …
mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is …
5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger
X Zheng, P Zheng, K Zhang, TC Cairns… - ACS synthetic …, 2018 - ACS Publications
The CRISPR/Cas9 system is a revolutionary genome editing tool. However, in eukaryotes,
search and optimization of a suitable promoter for guide RNA expression is a significant …
search and optimization of a suitable promoter for guide RNA expression is a significant …
[HTML][HTML] Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories
Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …
Secondary metabolite arsenal of an opportunistic pathogenic fungus
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
[HTML][HTML] A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi
The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species. A. …
approaches to discover and understand gene functions in a large number of fungal species. A. …
The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus
Some isolates of the opportunistic human pathogenic fungus Aspergillus fumigatus are known
to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which …
to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which …
Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks
…, N Paege, T Schuetze, TC Cairns… - Nucleic acids …, 2019 - academic.oup.com
A significant challenge in our understanding of biological systems is the high number of
genes with unknown function in many genomes. The fungal genus Aspergillus contains …
genes with unknown function in many genomes. The fungal genus Aspergillus contains …
[HTML][HTML] A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a …
Background Fungal fermentation is used to produce a diverse repertoire of enzymes, chemicals,
and drugs for various industries. During submerged cultivation, filamentous fungi form a …
and drugs for various industries. During submerged cultivation, filamentous fungi form a …