User profiles for Timothy C. Cairns

Timothy C Cairns

Senior Scientist, Technical University Berlin
Verified email at tu-berlin.de
Cited by 2510

[HTML][HTML] Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper

…, GH Braus, MX Caddick, TC Cairns… - Fungal biology and …, 2016 - Springer
The EUROFUNG network is a virtual centre of multidisciplinary expertise in the field of
fungal biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …

[HTML][HTML] How a fungus shapes biotechnology: 100 years of Aspergillus niger research

TC Cairns, C Nai, V Meyer - Fungal biology and biotechnology, 2018 - Springer
In 1917, a food chemist named James Currie made a promising discovery: any strain of the
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …

[HTML][HTML] The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

M Bertuzzi, M Schrettl, L Alcazar-Fuoli, TC Cairns… - PLoS …, 2014 - journals.plos.org
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the
mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is …

5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger

X Zheng, P Zheng, K Zhang, TC Cairns… - ACS synthetic …, 2018 - ACS Publications
The CRISPR/Cas9 system is a revolutionary genome editing tool. However, in eukaryotes,
search and optimization of a suitable promoter for guide RNA expression is a significant …

[HTML][HTML] Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Biotechnology for Biofuels, 2019 - Springer
Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …

Secondary metabolite arsenal of an opportunistic pathogenic fungus

E Bignell, TC Cairns… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …

[HTML][HTML] A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi

A Idnurm, AM Bailey, TC Cairns, CE Elliott… - Fungal Biology and …, 2017 - Springer
The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species. A. …

The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus

MF Bhatti, A Jamal, MA Petrou, TC Cairns… - Fungal Genetics and …, 2011 - Elsevier
Some isolates of the opportunistic human pathogenic fungus Aspergillus fumigatus are known
to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which …

Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks

…, N Paege, T Schuetze, TC Cairns… - Nucleic acids …, 2019 - academic.oup.com
A significant challenge in our understanding of biological systems is the high number of
genes with unknown function in many genomes. The fungal genus Aspergillus contains …

[HTML][HTML] A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a …

TC Cairns, C Feurstein, X Zheng, P Zheng, J Sun… - Biotechnology for …, 2019 - Springer
Background Fungal fermentation is used to produce a diverse repertoire of enzymes, chemicals,
and drugs for various industries. During submerged cultivation, filamentous fungi form a …