10.7554/eLife.24125.001 In plants, a complex mixture of solutes and macromolecules is
transported by the phloem. Here, we examined how solutes and macromolecules are separated …

Highlights • Biochemical studies suggest novel functional components in mature sieve tubes.
• Functions in, for example, signaling, protein turnover and degradation have been …

Contents Summary 35 I Overview of animal and plant WNK kinases 35 II. Structure:
domains and topology 36 III. Phylogeny–evolutionary relationships 41 IV. Plant WNK kinase …

In animals, endocytosis of a seven-transmembrane GPCR is mediated by arrestins to
propagate or arrest cytoplasmic G protein–mediated signaling, depending on the bias of the …

In plant cells, heterotrimeric G protein signaling mediates development, biotic/abiotic stress
responsiveness, hormone signaling, and extracellular sugar sensing. The amount of sugar in …

Biased signaling occurs when different ligands that are directed at the same receptor launch
different cellular outcomes. Because of their pharmacological importance, we know the …

Contents Summary 35 I Overview of animal and plant WNK kinases 35 II. Structure:
domains and topology 36 III. Phylogeny–evolutionary relationships 41 IV. Plant WNK kinase …

… To the Faculty of Washington State University: The members of the Committee appointed to
examine the dissertation of TIMOTHY J. ROSS-ELLIOTT find it satisfactory and recommend it …

Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP 2 ) to inositol 1,4,5-trisphosphate
(IP 3 ) and diacylglycerol (DAG). DAG and IP 3 each control diverse …

Background Most patients with Crohn's disease need an intestinal resection, but a majority
will subsequently experience disease recurrence and require further surgery. This study …