Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated that …

Activated microglia and reactive astrocytes invade and surround cerebral β amyloid (Aβ)
plaques in Alzheimer's disease (AD), but the role of microglia in plaque development is still …

Amyloid β (Aβ) protein immunotherapy lowers cerebral Aβ and improves cognition in mouse
models of Alzheimer's disease (AD). Here we show that Caribbean vervet monkeys (…

Lymphocyte trafficking is critically regulated by the Sphingosine 1-phosphate receptor-1 (S1P
1 ), a G protein-coupled receptor that has been highlighted as a promising therapeutic …

Amyloid-β (Aβ) immunotherapy lowers cerebral Aβ and improves cognition in mouse models
of Alzheimer's disease (AD). A clinical trial using active immunization with Aβ1–42 was …

Background Angiogenesis is a common finding in chronic inflammatory diseases; however,
its role in multiple sclerosis (MS) is unclear. Central nervous system lesions from both MS …

Alzheimer disease (AD), the most common form of dementia, is without an effective cure or
preventive treatment. Recently, amyloid-beta protein (Aβ) has become a major therapeutic …

Aims Sphingosine‐1‐phosphate receptor ( S 1 PR ) modulating therapies are currently in
the clinic or undergoing investigation for multiple sclerosis ( MS ) treatment. However, the …

In this study we examined the new cell dye CM-DiI for tracking the migration of lymphocytes
from blood to lymph. This lipophilic marker intercalates in the plasma membrane like the …

Immunization of humans and APP-tg mice with full-length β-amyloid (Aβ) results in reduced
cerebral Aβ levels. However, due to adverse events in the AN1792 trial, alternative vaccines …