Logic and memory are essential functions of circuits that generate complex, state-dependent
responses. Here we describe a strategy for efficiently assembling synthetic genetic circuits …

Synthetic biology involves the engineering of biological organisms by using modular and
generalizable designs with the ultimate goal of developing useful solutions to real-world …

Synthetic gene networks can be constructed to emulate digital circuits and devices, giving
one the ability to program and design cells with some of the principles of modern computing, …

Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …

RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the potential
to be integrated for the tunable modulation of gene networks. A major limitation of this …

More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …

Antimicrobial drug development is increasingly lagging behind the evolution of antibiotic
resistance, and as a result, there is a pressing need for new antibacterial therapies that can be …

Many natural biological systems—such as biofilms, shells and skeletal tissues—are able to
assemble multifunctional and environmentally responsive multiscale assemblies of living …

Current antibiotics tend to be broad spectrum, leading to indiscriminate killing of commensal
bacteria and accelerated evolution of drug resistance. Here, we use CRISPR-Cas …

Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease
detection and management but is impeded by access to the remote and complex environment. …