Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of
target tissues in animal models of non-insulin-dependent diabetes mellitus. In vitro, …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor
superfamily of ligand-dependent transcription factors that is predominantly expressed in …

Peroxisome proliferator-activated receptors (PPARs) α and γ are key regulators of lipid
homeostasis and are activated by a structurally diverse group of compounds including fatty acids, …

Bile acids regulate the transcription of genes that control cholesterol homeostasis through
molecular mechanisms that are poorly understood. Physiological concentrations of free and …

Prostaglandins(PGs) of the Jz series form in vivo and exert effects on a variety of biological
processes. While most PGs mediate their effects through G protein-coupled receptors, the …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent transcription
factor that is important in adipocyte differentiation and glucose homeostasis and which …

Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated with …

Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the
rate-limiting step in bile acid biosynthesis. Although bile acids activate the farnesoid X …

The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative
metabolism of a wide variety of xenobiotics including an estimated 60% of all clinically used drugs…

Steroid hormones exert profound effects on differentiation, development, and homeostasis in
higher eukaryotes through interactions with nuclear receptors. We describe a novel orphan …