β‐Lactam antibiotics are the most commonly used antibacterial agents and growing resistance
to these drugs is a concern. Metallo‐β‐lactamases are a diverse set of enzymes that …

New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the
penicillin, cephalosporin and ‘last resort’ carbapenems, and thus confers bacterial resistance to …

TEM-1 β-lactamase catalyzes the hydrolysis of β-lactam antibiotics such as the penicillins and
cephalosporins, thus providing for bacterial resistance to these compounds. To determine …

Unlike for classes A and B, a standardized amino acid numbering scheme has not been
proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. …

Vaccines and drugs have helped reduce disease severity and blunt the spread of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission…

The extensive and sometimes irresponsible use of beta-lactam antibiotics in clinical and
agricultural settings has contributed to the emergence and widespread dissemination of …

The most common mechanism of resistance to β-lactam antibiotics in Gram-negative bacteria
is the production of β-lactamases that hydrolyze the drugs. Class A β-lactamases are …

Virtually all transcription factors partner with coactivators that recruit chromatin remodeling
factors and interact with the basal transcription machinery. Coactivators have been implicated …

Ceftaroline is the first member of a novel class of cephalosporins approved for use in the
United States. Although prior studies have identified eight ceftaroline-resistant methicillin-…

The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of
Treponema pallidum subsp. pallidum were investigated based on previous screening studies …