Paternally inherited cis-regulatory structural variants are associated with autism

…, J Whitney, MS Maile, O Hong, TR Chapman… - Science, 2018 - science.org
The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from
de novo mutations in variant-intolerant genes. We hypothesize that rare inherited structural …

Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes

…, MG Frank, NY Crysdale, TR Chapman… - Journal of …, 2011 - Soc Neuroscience
We have previously found that healthy aged rats are more likely to suffer profound memory
impairments following a severe bacterial infection than are younger adult rats. Such a …

[PDF][PDF] Frequency and complexity of de novo structural mutation in autism

…, M Gujral, A Noor, G Rosanio, TR Chapman… - The American Journal of …, 2016 - cell.com
Genetic studies of autism spectrum disorder (ASD) have established that de novo duplications
and deletions contribute to risk. However, ascertainment of structural variants (SVs) has …

Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus

TR Chapman, RM Barrientos, JT Ahrendsen… - Neurobiology of …, 2012 - Elsevier
Aging increases the likelihood of cognitive decline after negative life events such as
infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but …

Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term …

TR Chapman, RM Barrientos… - Journal of …, 2010 - Soc Neuroscience
Variability in cognitive functioning increases markedly with age, as does cognitive vulnerability
to physiological and psychological challenges. Exploring the basis of this vulnerability …

Paternally inherited noncoding structural variants contribute to autism

…, ML Kleiber, MS Maile, O Hong, TR Chapman… - bioRxiv, 2017 - biorxiv.org
The genetic architecture of autism spectrum disorder (ASD) is known to consist of contributions
from gene-disrupting de novo mutations and common variants of modest effect. We …

Neurologic deficit following percutaneous vertebral stabilization

…, JA Youssef, DE Gelb, HH Mathews, JR Chapman… - Spine, 2007 - journals.lww.com
Study Design. A retrospective review. Objective. The purpose of this study is to document a
series of cases of neurologic deficit following percutaneous vertebral stabilization, to identify …

[HTML][HTML] Wastewater monitoring can anchor global disease surveillance systems

…, JM Brault, JB Burnet, JR Chapman… - The Lancet Global …, 2023 - thelancet.com
To inform the development of global wastewater monitoring systems, we surveyed programmes
in 43 countries. Most programmes monitored predominantly urban populations. In high-…

[PDF][PDF] Gabriel Rosanio, Timothy R. Chapman, Daniel J. Barrera, Guan Ning Lin, 2

D Malhotra, AC Watts, LC Wong, JA Estabillo, R Owen… - 2016 - researchgate.net
Genetic studies of autism spectrum disorder (ASD) have established that de novo duplications
and deletions contribute to risk. However, ascertainment of structural variants (SVs) has …

Inflight performance characteristics, calibration, and utilization of the Galileo solid state imaging camera

…, M Davies, RJ Sullivan, CR Chapman… - Optical …, 1997 - spiedigitallibrary.org
The solid-state imaging subsystem (SSI) on NASA’s Galileo Jupiter orbiter spacecraft has
already demonstrated its superior performance as a scientific imager by returning stunning …