Biomolecular systems possess unique, structure-encoded dynamic properties that underlie
their biological functions. Recent studies indicate that these dynamic properties are …

A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths and …

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors
transmitting extracellular signals into cells. Here we show that central components of a …

We describe a method based on the principle of entropy maximization to identify the gene
interaction network with the highest probability of giving rise to experimentally observed …

Correlations between sequence evolution and structural dynamics are of utmost importance
in understanding the molecular mechanisms of function and their evolution. We have …

One of the greatest challenges in biomedical research, drug discovery and diagnostics is
understanding how seemingly identical cells can respond differently to perturbagens including …

Substrate transport in sodium-coupled amino acid symporters involves a large-scale
conformational change that shifts the access to the substrate-binding site from one side of the …

Comparison of elastic network model predictions with experimental data has provided
important insights on the dominant role of the network of inter-residue contacts in defining the …

Insulin and insulin-like growth factor I (IGF1) influence cancer risk and progression through
poorly understood mechanisms. To better understand the roles of insulin and IGF1 signaling …

We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment),
an open-source tool developed to assist cancer researchers in interactive hypothesis …