User profiles for Timothy W. Craven
Timothy W. CravenUniversity of Washington Verified email at uw.edu Cited by 946 |
[PDF][PDF] Accurate de novo design of membrane-traversing macrocycles
…, M Di Piazza, X Li, P Hosseinzadeh, TW Craven… - Cell, 2022 - cell.com
We use computational design coupled with experimental characterization to systematically
investigate the design principles for macrocycle membrane permeability and oral …
investigate the design principles for macrocycle membrane permeability and oral …
Comprehensive computational design of ordered peptide macrocycles
Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent
therapeutics identified to date, but there is currently no way to systematically search the structural …
therapeutics identified to date, but there is currently no way to systematically search the structural …
Cyclic Peptide Screening Methods for Preclinical Drug Discovery: Miniperspective
X Li, TW Craven, PM Levine - Journal of Medicinal Chemistry, 2022 - ACS Publications
Cyclic peptides are among the most diverse architectures for current drug discovery efforts.
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O-…
inhibition of protein aggregation. Most of the previous studies in this area focused on O-…
[HTML][HTML] Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Despite recent success in computational design of structured cyclic peptides, de novo design
of cyclic peptides that bind to any protein functional site remains difficult. To address this …
of cyclic peptides that bind to any protein functional site remains difficult. To address this …
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such
as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β-lactam …
as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β-lactam …
[HTML][HTML] Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
JA Schneider, TW Craven, AC Kasper, C Yun… - Nature …, 2018 - nature.com
New chemical inhibitors of protein–protein interactions are needed to propel advances in
molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit …
molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit …
[HTML][HTML] Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor
Despite the increasing number of GPCR structures and recent advances in peptide design,
the development of efficient technologies allowing rational design of high-affinity peptide …
the development of efficient technologies allowing rational design of high-affinity peptide …
[HTML][HTML] Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design
Peptidomimetics are classes of molecules that mimic structural and functional attributes of
polypeptides. Peptidomimetic oligomers can frequently be synthesized using efficient solid …
polypeptides. Peptidomimetic oligomers can frequently be synthesized using efficient solid …
The sulfur-linked analogue of O-GlcNAc (S-GlcNAc) is an enzymatically stable and reasonable structural surrogate for O-GlcNAc at the peptide and protein levels
Synthetic proteins bearing site-specific posttranslational modifications have revolutionized
our understanding of their biological functions in vitro and in vivo. One such modification, O-…
our understanding of their biological functions in vitro and in vivo. One such modification, O-…