Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the
current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of SARS-…

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

Cells adjust to nutrient deprivation by reversible translational shutdown. This is accompanied
by maintaining inactive ribosomes in a hibernation state, in which they are bound by …

Reactive aldehydes are abundant endogenous metabolites that challenge homeostasis by
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …

In eukaryotic translation, termination and ribosome recycling phases are linked to subsequent
initiation of a new round of translation by persistence of several factors at ribosomal sub‐…

Cotranslational modification of the nascent polypeptide chain is one of the first events during
the birth of a new protein. In eukaryotes, methionine aminopeptidases (MetAPs) cleave off …

Stalled ribosomes are rescued by pathways that recycle the ribosome and target the nascent
polypeptide for degradation. In E. coli, these pathways are triggered by ribosome collisions …

SARS-CoV-2 is the causative agent of the current COVID-19 pandemic. A major virulence
factor of SARS-CoVs is the nonstructural protein 1 (Nsp1) which suppresses host gene …

… Carsten Grohmann, René Werner, Timur Mackens-Kiani, Thorsten Frenzel, Florian Cremers …

Cell-free platforms have been key in the rapid advancement of synthetic biology. They
enable the design of metabolic pathways for the production of any desired proteins. Cell-free …