The human deafness dystonia syndrome results from the mutation of a protein (DDP) of
unknown function. We show now that DDP is a mitochondrial protein and similar to five small …

Tim10p, a protein of the yeast mitochondrial intermembrane space, was shown previously
to be essential for the import of multispanning carrier proteins from the cytoplasm into the …

We have identified a 20 kDa yeast mitochondrial outer membrane protein (termed MAS20)
which appears to function as a protein import receptor. We cloned, sequenced and physically …

Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic
reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon …

Protein targeting to the endoplasmic reticulum is mediated by signal or signal-anchor
sequences. They also play an important role in protein topogenesis, because their orientation in …

Mitochondrial precursor proteins made in the cytosol bind to a hetero‐oligomeric protein
import receptor on the mitochondrial surface and then pass through the translocation channel …

We have cloned the gene encoding the protein Mas22p, which spans the outer membrane
of yeast mitochondria. Cells that completely lack Mas22p are inviable. The plasmid-borne …

Membrane protein insertion and topogenesis generally occur at the Sec61 translocon in the
endoplasmic reticulum membrane. During this process, membrane spanning segments may …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many membrane …

The Sec61 translocon mediates the translocation of proteins across the endoplasmic reticulum
membrane and the lateral integration of transmembrane segments into the lipid bilayer. …