[HTML][HTML] Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral …
N Bakkar, T Kovalik, I Lorenzini, S Spangler… - Acta …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no
effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in …
effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in …
Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis
…, PS Estes, J Johannesmeyer, T Kovalik… - Journal of …, 2014 - Soc Neuroscience
TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is
known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. …
known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. …
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
…, AG O'Conner, JM Barrows, A Starr, T Kovalik… - Elife, 2019 - elifesciences.org
10.7554/eLife.45114.001 Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative
disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila …
disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila …
Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes
L Vu, J An, T Kovalik, T Gendron, L Petrucelli… - Journal of Neurology …, 2020 - jnnp.bmj.com
Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous pathological
mechanisms resulting in a heterogeneous patient population. Using biomarkers for …
mechanisms resulting in a heterogeneous patient population. Using biomarkers for …
[HTML][HTML] The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with …
RNA-binding protein pathology now represents one of the best characterized pathologic
features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration patients …
features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration patients …
[HTML][HTML] Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo
DX Medina, KT Householder, R Ceton, T Kovalik… - Journal of Controlled …, 2017 - Elsevier
Understanding of the mechanisms by which systemically administered nanoparticles achieve
delivery across biological barriers remains incomplete, due in part to the challenge of …
delivery across biological barriers remains incomplete, due in part to the challenge of …
[HTML][HTML] TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
…, S Loganathan, E Alsop, AD Blythe, T Kovalik… - Acta neuropathologica …, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative
disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA binding …
disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA binding …
RBM45 modulates the antioxidant response in amyotrophic lateral sclerosis through interactions with KEAP1
N Bakkar, A Kousari, T Kovalik, Y Li… - Molecular and cellular …, 2015 - Am Soc Microbiol
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the selective loss of motor neurons. Various factors contribute to the disease, including RNA …
the selective loss of motor neurons. Various factors contribute to the disease, including RNA …
Retinoic acid receptor‐mediated neuroprotection and its implications for amyotrophic lateral sclerosis
CL Kolarcik, T Kovalik, R Bowser - 2011 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is the most common form of adult onset motor neuron
disease and is characterized by the progressive degeneration and death of motor neurons. …
disease and is characterized by the progressive degeneration and death of motor neurons. …
Dysregulation of mRNA Transport and Translation in ALS
AN Coyne - 2016 - repository.arizona.edu
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting
upper and lower motor neurons. Although many cellular processes such as cytoskeletal …
upper and lower motor neurons. Although many cellular processes such as cytoskeletal …