The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth
characterization of tendon cells and their precursors. We show that human and mouse …

Although extracellular control of canonical Wnt signaling is crucial for tissue homeostasis,
the role of the extracellular microenvironment in modulating this signaling pathway is largely …

Wnt‐induced secreted protein 1 (WISP‐1/CCN4) is a member of the CCN family that is highly
expressed in skeletal tissue and in osteoprogenitor cells induced to differentiate in vitro. To …

The temporomandibular joint is critical for jaw movements and allows for mastication, digestion
of food, and speech. Temporomandibular joint osteoarthritis is a degenerative disease …

Nutrition plays a significant role in the increasing prevalence of metabolic and brain disorders.
Here we employ systems nutrigenomics to scrutinize the genomic bases of nutrient–host …

Matrix proteoglycans such as biglycan (Bgn) dominate skeletal tissue and yet its exact role
in regulating bone function is still unclear. In this paper we describe the potential role of (Bgn) …

WISP1/CCN4 (hereafter referred to as WISP1), a member of the CCN family, is found in
mineralized tissues and is produced by osteoblasts and their precursors. In this study, Wisp1-…

Understanding the mechanisms that control cutaneous wound healing is crucial to successfully
manage repair of damaged skin. The goal of the current study was to uncover novel …

Bone mass is maintained by a fine balance between bone formation by osteoblasts and
bone resorption by osteoclasts. Although osteoblasts and osteoclasts have different …

Biglycan (Bgn) and Fibromodulin (Fmod) are subtypes of the small leucine-rich family of
proteoglycans (SLRP). In this study we examined the skeletal phenotype of BgnFmod double …