How tumor cells genetically lose antigenicity and evade immune checkpoints remains largely
elusive. We report that tissue-specific expression of the human long noncoding RNA LINK-…

Objective We characterised the clinical course, treatment and outcomes in 59 patients with
relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. …

ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1
has unique substrate preferences, trimming long peptides but sparing shorter ones. To …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer
treatment but are associated with myocarditis. Here, we report that tumor-bearing mice …

This guide provides a single, comprehensive document with methods for evaluating the
safety and operations of signalized intersections and tools to remedy deficiencies. The …

We retrospectively analyzed 65 patients with refractory/relapsed (r/r) ALL who were treated
with blinatumomab for predictors of leukemia response as well as clinical patterns of relapse …

Leucocyte infiltration in the decidua (maternal–foetal interface) before, during and after term
( TL ) and preterm labour ( PTL ) was studied in mouse. We also investigated the …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal
recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) …

Heterozygous loss-of-function (LOF) mutations in PIK3R1 (encoding phosphatidylinositol 3-kinase
[PI3K] regulatory subunits) cause activated PI3Kδ syndrome 2 (APDS2), which has a …