Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory bowel
disease (IBD). The oxysterol receptor GPR183 and its ligands, dihydroxylated oxysterols, …

The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a
risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-…

Background and Aims pH-sensing ovarian cancer G-protein coupled receptor-1 [OGR1/GPR68]
is regulated by key inflammatory cytokines. Patients suffering from inflammatory bowel …

Nonalcoholic steatohepatitis (NASH), a primary cause of liver disease, leads to
complications such as fibrosis, cirrhosis, and carcinoma, but the pathophysiology of NASH is …

Intestinal fibrosis and stenosis are common complications of Crohn’s disease [CD], frequently
requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, …

Colorectal cancer (CRC) is one of the leading causes of cancer‐related deaths worldwide
and the need for novel biomarkers and therapeutic strategies to improve diagnosis and …

Background Fibroblast growth factor (FGF) 15/19 is part of the gut-liver crosstalk accounting
for bile acid (BA) metabolism regulation. Dysregulation of fibroblast growth factor 15/19 …

Background/Aims: The protein tyrosine phosphatase non-receptor type 2 (PTPN2) is known
to mediate susceptibility to inflammatory bowel diseases. Cell culture experiments suggest …

Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic
steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The “…

Inflammasomes are large, multiprotein complexes that form upon cytosolic or nuclear
presence of damage-or pathogen-associated molecular patterns, ultimately leading to the …