Gut microbiota plays an important role in the bidirectional communication between the gut
and the central nervous system. Mounting evidence suggests that gut microbiota can …

Hippocampus plays an important role in learning and memory and in spatial navigation.
Production of new neurons that are functionally integrated into the hippocampal neuronal …

Hippocampal-dependent cognitive functions rely on production of new neurons and
maintenance of dendritic structures to provide the synaptic plasticity needed for learning and …

The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical
scavenging enzyme that is the first line of defense against superoxide produced as a …

Mice heterozygous for the Sod2 gene (Sod2 +/− mice) have been used to study the phenotype
of life-long reduced Mn-superoxide dismutase (MnSOD) activity. The Sod2 +/− mice have …

Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities
during development and early adulthood, but had a reduced lifespan and increased incidence …

Oxidative stress has been implicated in many diseases. The chief source of reactive oxygen
species within the cell is the mitochondrion. We have characterized a variety of the …

This study characterizes mitochondria isolated from livers of Sod2 −/+ and Sod2 +/+ mice. A
50% decrease in manganese superoxide dismutase (MnSOD) activity was observed in …

We describe a novel phenotype in mice lacking the major antioxidant enzyme, CuZn-superoxide
dismutase (Sod1 −/− mice), namely a dramatic acceleration of age-related loss of …

Apoptotic neuronal cell death has recently been associated with the development of
infarction after cerebral ischemia. In a variety of studies, CuZn-superoxide dismutase (CuZn-SOD) …