Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA
damage checkpoints. Here we show that overexpression of TRF2 affects the response of …

Human telomere length is controlled by a negative feedback loop based on the binding of
TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …

When telomeres are rendered dysfunctional through replicative attrition of the telomeric DNA
or by inhibition of shelterin 1 , cells show the hallmarks of ataxia telangiectasia mutated (…

The telomere end-protection problem is defined by the aggregate of DNA damage signaling
and repair pathways that require repression at telomeres. To define the end-protection …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA and
protect the ends from degradation and fusion. In human cells, telomere protection depends on …

The ends of eukaryotic chromosomes have the potential to be mistaken for damaged or
broken DNA and must therefore be protected from cellular DNA damage response pathways. …

Primary human cells in culture invariably stop dividing and enter a state of growth arrest
called replicative senescence. This transition is induced by programmed telomere shortening, …