[HTML][HTML] Engineered extracellular vesicles from human periodontal-ligament stem cells increase VEGF/VEGFR2 expression during bone regeneration

J Pizzicannella, A Gugliandolo, T Orsini… - Frontiers in …, 2019 - frontiersin.org
Bone regeneration represents still a challenge, in particular for calvarium defects. Recently,
the development of biomaterials with the addiction of stem cells is giving promising results …

[HTML][HTML] 3D printing PLA/gingival stem cells/EVs upregulate miR-2861 and-210 during osteoangiogenesis commitment

…, L Chiricosta, P Bramanti, I Merciaro, T Orsini… - International Journal of …, 2019 - mdpi.com
Bone tissue regeneration strategies require approaches that provide an osteogenic and
angiogenic microenvironment able to drive the bone growth. Recently, the development of 3D …

[HTML][HTML] Biofunctionalized scaffold in bone tissue repair

…, A Gugliandolo, I Merciaro, T Orsini… - International journal of …, 2018 - mdpi.com
Bone tissue engineering is based on bone grafting to repair bone defects. Bone graft substitutes
can contribute to the addition of mesenchymal stem cells (MSCs) in order to enhance …

Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death

L Pica-Mattoccia, T Orsini, A Basso, A Festucci… - Experimental …, 2008 - Elsevier
The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of
calcium into the worms, suggesting that this phenomenon could be the source of the observed …

[HTML][HTML] Biomimetic surfaces coated with covalently immobilized collagen type I: An x-ray photoelectron spectroscopy, atomic force microscopy, micro-CT and …

A Scarano, F Lorusso, T Orsini, M Morra… - International Journal of …, 2019 - mdpi.com
Background: The process of osseointegration of dental implants is characterized by healing
phenomena at the level of the interface between the surface and the bone. Implant surface …

[HTML][HTML] Graphene-doped poly (methyl-methacrylate)(PMMA) implants: A micro-CT and histomorphometrical study in rabbits

A Scarano, T Orsini, F Di Carlo, L Valbonetti… - International Journal of …, 2021 - mdpi.com
Background—the graphene-doping procedure represents a useful procedure to improve
the mechanical, physical and biological response of several Polymethyl methacrylate (PMMA)-…

[HTML][HTML] FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

…, A Manduca, A Rava, V Buzzelli, F Ascone, T Orsini… - Scientific Reports, 2022 - nature.com
Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder emerging in
early life characterized by impairments in social interaction, poor verbal and non-verbal …

[HTML][HTML] Three-dimensional X-ray imaging of β-galactosidase reporter activity by micro-CT: Implication for quantitative analysis of gene expression

O Ermakova, T Orsini, P Fruscoloni, F Chiani… - Brain Sciences, 2021 - mdpi.com
Acquisition of detailed anatomical and molecular knowledge from intact biological samples
while preserving their native three-dimensional structure is still a challenging issue for …

[HTML][HTML] Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

S Cardarelli, M Biglietto, T Orsini, V Fustaino… - Cell Death & …, 2024 - nature.com
Phosphodiesterase 2A (Pde2A) is a dual-specific PDE that breaks down both cAMP and
cGMP cyclic nucleotides. We recently highlighted a direct relationship between Pde2A …

[HTML][HTML] PDE2A is indispensable for mouse liver development and hematopoiesis

…, V Rotilio, MR Assenza, S Aguanno, T Orsini… - International Journal of …, 2020 - mdpi.com
Phosphodiesterase 2A (PDE2A) is a cAMP-cGMP hydrolyzing enzyme essential for mouse
development and the PDE2A knockout model (PDE2A −/− ) is embryonic lethal. Notably, …