[PDF][PDF] Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome

…, M Kreuz, I Leuschner, JIM Subero, T Obser… - The American Journal of …, 2010 - cell.com
Rhabdoid tumors of early infancy are highly aggressive with consequent poor prognosis.
Most cases show inactivation of the SMARCB1 (also known as INI1 and hSNF5) tumor …

Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression

…, AR Judkins, MC Frühwald, T Obser… - The American journal …, 2011 - journals.lww.com
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive brain tumors of early
childhood poorly responding to therapy. The majority of cases show inactivation of SMARCB1 (…

von Willebrand factor cleaving protease and ADAMTS13mutations in childhood TTP

…, K Kurnik, D Mueller-Wiefel, T Obser… - Blood, The Journal …, 2003 - ashpublications.org
Thrombotic thrombocytopenic purpura (TTP) is caused by the persistence of the highly reactive
high-molecular-weight multimers of von Willebrand factor (VWF) due to deficiency of the …

von Willebrand factor directly interacts with DNA from neutrophil extracellular traps

…, F Gräter, R Schneppenheim, T Obser… - … , and vascular biology, 2014 - Am Heart Assoc
Objective— Inflammatory conditions provoke essential processes in the human vascular
system. It leads to the formation of ultralarge von Willebrand factor (VWF) fibers, which are …

[HTML][HTML] Shear‐induced unfolding activates von Willebrand factor A2 domain for proteolysis

…, R Schneppenheim, W Stacklies, T Obser… - Journal of Thrombosis …, 2009 - Elsevier
Background: To avoid pathological platelet aggregation by von Willebrand factor (VWF),
VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13‐mediated …

[PDF][PDF] Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions

…, AK Bronowska, S Grässle, MA Brehm, T Obser… - Biophysical journal, 2015 - cell.com
Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it
adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to …

[PDF][PDF] Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers

S Lippok, M Radtke, T Obser, L Kleemeier… - Biophysical journal, 2016 - cell.com
Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by
ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF …

Ultralarge von Willebrand Factor Fibers Mediate Luminal Staphylococcus aureus Adhesion to an Intact Endothelial Cell Layer Under Shear Stress

…, C Weidenmaier, R Schneppenheim, T Obser… - Circulation, 2013 - Am Heart Assoc
Background— During pathogenesis of infective endocarditis, Staphylococcus aureus
adherence often occurs without identifiable preexisting heart disease. However, molecular …

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis

WA Hassenpflug, U Budde, T Obser, D Angerhaus… - Blood, 2006 - ashpublications.org
Classical von Willebrand disease (VWD) type 2A, the most common qualitative defect of VWD,
is caused by loss of high-molecular-weight multimers (HMWMs) of von Willebrand factor (…

Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

…, SM Sedlak, S Gruber, T Obser… - Proceedings of the …, 2019 - National Acad Sciences
Single-molecule force spectroscopy has provided unprecedented insights into protein
folding, force regulation, and function. So far, the field has relied primarily on atomic force …