Aerobic life consumes oxygen for efficient production of high energy compounds. The ability
to sense and respond to changes in oxygen partial pressure represents a fundamental …

Importance Somatic mutations causing clonal expansion of hematopoietic cells (clonal
hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated with …

Hypoxia inducible factor 1 (HIF-1), a heterodimeric transcription factor composed of HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. The …

Tissue regenerative potential displays striking divergence across phylogeny and ontogeny,
but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative …

Oxygen sensing and reactivity to changes in the concentration of oxygen is a fundamental
property of cell physiology. The lack of O 2 (hypoxia) is transmitted into many adaptive …

Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological, …

Peroxisome proliferator-activated receptor γ (PPARγ) gained considerable interest as a
therapeutic target during chronic inflammatory diseases. Remarkably, the pathogenesis of …

Hypoxia-inducible factor-1 (HIF-1) is a regulator of metabolic adaptation to hypoxia. It is now
appreciated that HIF-1α accumulation is achieved under normoxic conditions by various …

HIF-1 (hypoxia-inducible factor-1), a heterodimeric transcription factor comprising HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. HIF-1 …

Inactivation of tumor suppressors is among the rate-limiting steps in carcinogenesis that
occur during the tumor promotion stage. The translation inhibitor programmed cell death 4 (…