Foxp3 + regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that
remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular …

10.7554/eLife.32417.001 Calcium is an essential cellular messenger that regulates numerous
functions in living organisms. Here, we describe development and characterization of ‘…

T lymphocyte motility and interaction dynamics with other immune cells are vital determinants
of immune responses. Regulatory T (Treg) cells prevent autoimmune disorders by …

10.7554/eLife.27827.001 Ca 2+ influx through Orai1 channels is crucial for several T cell
functions, but a role in regulating basal cellular motility has not been described. Here, we show …

Four loci have been associated with pancreatic cancer through genome-wide association
studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to …

Although dietary calcium intake has long been recommended for disease prevention, the
influence of calcium in development of cancer in the upper gastrointestinal tract has not been …

Foxp3+ regulatory T cells (Tregs) maintain immune homeostasis through mechanisms that
remain incompletely defined. Here, by two-photon imaging, we examine the cellular …

Although purinegic signaling is important in regulating gastric physiological functions, it is
currently unknown for its role in gastric cancer (GC). We demonstrate for the first time that the …

Although VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal
physiology, their involvements in progression of gastrointestinal tumor have not been …

The calcium sensing receptor (CaSR) is functionally expressed in normal human pancreases,
but its pathological role in pancreatic tumorigenesis is currently unknown. We sought to …