[HTML][HTML] Identification, expression, and substrate specificity of a mammalian β-carotene 15, 15′-dioxygenase
TM Redmond, S Gentleman, T Duncan, S Yu… - Journal of Biological …, 2001 - ASBMB
We have identified from mouse the first mammalian β-carotene 15,15′-dioxygenase (β-CD),
a crucial enzyme in development and metabolism that governs the de novo entry of vitamin …
a crucial enzyme in development and metabolism that governs the de novo entry of vitamin …
[HTML][HTML] Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells
…, C Jaworski, OA Postnikova, RK Kutty, T Duncan… - Molecular …, 2017 - ncbi.nlm.nih.gov
Purpose The RPE cell line ARPE-19 provides a dependable and widely used alternative to
native RPE. However, replication of the native RPE phenotype becomes more difficult …
native RPE. However, replication of the native RPE phenotype becomes more difficult …
[HTML][HTML] Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and …
…, C Vijayasarathy, C Jaworski, T Duncan… - Molecular …, 2013 - ncbi.nlm.nih.gov
Purpose The inflammatory response of the retinal pigment epithelium (RPE) is implicated in
the pathogenesis of age-related macular degeneration. The microRNAs miR-146a and miR-…
the pathogenesis of age-related macular degeneration. The microRNAs miR-146a and miR-…
[HTML][HTML] CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder.
Although molecular mechanisms remain elusive, deficits in autophagy have been associated …
Although molecular mechanisms remain elusive, deficits in autophagy have been associated …
[HTML][HTML] MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl) retinamide
RK Kutty, W Samuel, C Jaworski, T Duncan… - Molecular …, 2010 - ncbi.nlm.nih.gov
Purpose MicroRNAs (miRNAs) are important regulators of many cellular functions due to
their ability to target mRNAs for degradation or translational inhibition. Previous studies have …
their ability to target mRNAs for degradation or translational inhibition. Previous studies have …
[HTML][HTML] Proinflammatory cytokines decrease the expression of genes critical for RPE function
…, W Samuel, K Boyce, A Cherukuri, T Duncan… - Molecular …, 2016 - ncbi.nlm.nih.gov
Purpose Proinflammatory cytokines interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α),
and interleukin-1 beta (IL-1β) secreted by infiltrating lymphocytes or macrophages …
and interleukin-1 beta (IL-1β) secreted by infiltrating lymphocytes or macrophages …
Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome
…, WM Zein, S Riaz, APJ Giese, JM Schultz, T Duncan… - Elife, 2021 - elifesciences.org
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and
progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (…
progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (…
[HTML][HTML] Molecular Characterization and Developmental Expression ofNORPEG, a Novel Gene Induced by Retinoic Acid
RK Kutty, G Kutty, W Samuel, T Duncan… - Journal of Biological …, 2001 - ASBMB
We have characterized NORPEG, a novel gene from human retinal pigment epithelial cells (ARPE-19),
in which its expression is induced by all-trans-retinoic acid. Two transcripts (∼3 …
in which its expression is induced by all-trans-retinoic acid. Two transcripts (∼3 …
[HTML][HTML] Molecular characterization and developmental expression of a retinoid-and fatty acid-binding glycoprotein from Drosophila: A putative lipophorin
RK Kutty, G Kutty, R Kambadur, T Duncan… - Journal of Biological …, 1996 - ASBMB
A detailed understanding of the mechanism of lipid transport in insects has been hampered
by the inability to identify the proapolipophorin gene that encodes apolipophorins I and II, the …
by the inability to identify the proapolipophorin gene that encodes apolipophorins I and II, the …
Identification of a New Member of Transforming Growth Factor-Beta Superfamily inDrosophila: The First Invertebrate Activin Gene
G Kutty, RK Kutty, W Samuel, T Duncan… - Biochemical and …, 1998 - Elsevier
Activins, a subgroup of the transforming growth factor-β (TGF-β) superfamily, have been
extensively studied in vertebrates for their roles in growth and development. However, activins …
extensively studied in vertebrates for their roles in growth and development. However, activins …