User profiles for Todd J. Herron
Todd J HerronUniversity of Michigan Verified email at umich.edu Cited by 5561 |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia,
we performed a genome-wide association study of >1,000,000 people, including 60,620 …
we performed a genome-wide association study of >1,000,000 people, including 60,620 …
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
Rationale: Cardiomyocytes (CMs) differentiated from human pluripotent stem cells (PSCs)
are increasingly being used for cardiovascular research, including disease modeling, and …
are increasingly being used for cardiovascular research, including disease modeling, and …
Optical imaging of voltage and calcium in cardiac cells & tissues
Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well-…
function and disease. The development and scientific impact of this methodology are well-…
Extracellular matrix–mediated maturation of human pluripotent stem cell–derived cardiac monolayer structure and electrophysiological function
Background— Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) monolayers
generated to date display an immature embryonic-like functional and structural phenotype …
generated to date display an immature embryonic-like functional and structural phenotype …
Small amounts of α-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments
TJ Herron, KS McDonald - Circulation research, 2002 - Am Heart Assoc
Myocardial performance is likely affected by the relative expression of the two myosin heavy
chain (MyHC) isoforms, namely α-MyHC and β-MyHC. The relative expression of each …
chain (MyHC) isoforms, namely α-MyHC and β-MyHC. The relative expression of each …
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers
Rationale: Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) offer
a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific …
a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific …
[HTML][HTML] Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors
Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease.
The limited availability of human CFs from native heart impedes investigations of CF …
The limited availability of human CFs from native heart impedes investigations of CF …
Loaded shortening and power output in cardiac myocytes are dependent on myosin heavy chain isoform expression
TJ Herron, FS Korte… - American Journal of …, 2001 - journals.physiology.org
The purpose of this study was to examine the role of myosin heavy chain (MHC) in determining
loaded shortening velocities and power output in cardiac myocytes. Cardiac myocytes …
loaded shortening velocities and power output in cardiac myocytes. Cardiac myocytes …
[HTML][HTML] Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes
Histone H3 lysine 4 (H3K4me) methyltransferases and their cofactors are essential for
embryonic development and the establishment of gene expression patterns in a cell-specific and …
embryonic development and the establishment of gene expression patterns in a cell-specific and …
[HTML][HTML] Role of extracellular histones in the cardiomyopathy of sepsis
The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male
C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular …
C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular …