User profiles for Todd J. Herron

Todd J Herron

University of Michigan
Verified email at umich.edu
Cited by 5561

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

…, W Zhou, MW Skov, SE Graham, TJ Herron… - Nature …, 2018 - nature.com
To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia,
we performed a genome-wide association study of >1,000,000 people, including 60,620 …

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method

…, GE Lyons, JA Thomson, TJ Herron, J Jalife… - Circulation …, 2012 - Am Heart Assoc
Rationale: Cardiomyocytes (CMs) differentiated from human pluripotent stem cells (PSCs)
are increasingly being used for cardiovascular research, including disease modeling, and …

Optical imaging of voltage and calcium in cardiac cells & tissues

TJ Herron, P Lee, J Jalife - Circulation research, 2012 - Am Heart Assoc
Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well-…

Extracellular matrix–mediated maturation of human pluripotent stem cell–derived cardiac monolayer structure and electrophysiological function

TJ Herron, AMD Rocha, KF Campbell… - Circulation …, 2016 - Am Heart Assoc
Background— Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) monolayers
generated to date display an immature embryonic-like functional and structural phenotype …

Small amounts of α-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments

TJ Herron, KS McDonald - Circulation research, 2002 - Am Heart Assoc
Myocardial performance is likely affected by the relative expression of the two myosin heavy
chain (MyHC) isoforms, namely α-MyHC and β-MyHC. The relative expression of each …

Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers

…, G Guerrero-Serna, P Kohl, J Jalife, TJ Herron - Circulation …, 2012 - Am Heart Assoc
Rationale: Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) offer
a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific …

[HTML][HTML] Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

…, AN Raval, AM Da Rocha, TJ Herron, J Jalife… - Nature …, 2019 - nature.com
Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease.
The limited availability of human CFs from native heart impedes investigations of CF …

Loaded shortening and power output in cardiac myocytes are dependent on myosin heavy chain isoform expression

TJ Herron, FS Korte… - American Journal of …, 2001 - journals.physiology.org
The purpose of this study was to examine the role of myosin heavy chain (MHC) in determining
loaded shortening velocities and power output in cardiac myocytes. Cardiac myocytes …

[HTML][HTML] Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes

AB Stein, TA Jones, TJ Herron, SR Patel… - The Journal of …, 2011 - Am Soc Clin Investig
Histone H3 lysine 4 (H3K4me) methyltransferases and their cofactors are essential for
embryonic development and the establishment of gene expression patterns in a cell-specific and …

[HTML][HTML] Role of extracellular histones in the cardiomyopathy of sepsis

…, JJ Grailer, F Fattahi, L Jajou, TJ Herron… - The FASEB …, 2015 - ncbi.nlm.nih.gov
The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male
C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular …