Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are
characterized by early peaks of viraemia that decline as strong cellular immune responses …

Exhausted T cells in cancer and chronic viral infection express distinctive patterns of genes,
including sustained expression of programmed cell death protein 1 (PD-1). However, the …

Decline of peak viremia during acute HIV-1 infection occurs before the development of
vigorous adaptive immunity, and the level of decline correlates inversely with the rate of AIDS …

Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy
and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant …

Natural killer (NK) cells have an important role in the control of viral infections, recognizing
virally infected cells through a variety of activating and inhibitory receptors 1 , 2 , 3 . …

Background: HLA-B57, as well as cytotoxic T-lymphocyte (CTL) responses restricted by this
allele, have been strongly associated with long-term non-progressive chronic HIV-1 infection…

Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease
inhibitors in <1% of the viral quasispecies may still allow >1000‐fold viral load reductions upon …

Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …

The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major
obstacle to the development of an effective vaccine, yet the forces impacting the evolution of …

Background Very little is known about the immunodominance patterns of HIV-1-specific T cell
responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (…