CD4 + T helper (Th) cells are critical for proper immune cell homeostasis and host defense,
but are also major contributors to pathology of autoimmune and inflammatory diseases. …

Programmed death 1 (PD-1) is an inhibitory molecule expressed on activated T cells; however,
the biological context in which PD-1 controls T cell tolerance remains unclear. Using two-…

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2, has spread globally, and no proven treatments are available. Convalescent plasma …

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2, has spread globally, and proven treatments are limited. Transfusion of …

The past decade has seen a significant increase in the number of potentially tolerogenic
therapies for treatment of new-onset diabetes. However, most treatments are antigen …

Coronavirus disease 2019 (COVID-19) convalescent plasma has emerged as a promising
therapy and has been granted Emergency Use Authorization by the US Food and Drug …

Relapsing experimental autoimmune encephalomyelitis (R-EAE) is a CD4+ T cell-mediated
demyelinating disease model for multiple sclerosis. Myelin destruction during the initial …

Notch signaling has been identified as an important regulator of leukocyte differentiation and
thymic maturation. Less is known about the role of Notch signaling in regulating mature T …

Objective To extend our studies on the prolonged and differential effect of natalizumab on T
lymphocyte numbers in the cerebrospinal fluid, we investigated the number and phenotypes …

Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and
mortality rates. The emergence and spread of strains resistant to multiple antimicrobial agents …