VEGF-A expression by HSV-1–infected cells drives corneal lymphangiogenesis

TR Wuest, DJJ Carr - Journal of Experimental Medicine, 2010 - rupress.org
Inflammatory lymphangiogenesis plays a crucial role in the development of inflammation and
transplant rejection. The mechanisms of inflammatory lymphangiogenesis during bacterial …

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection

…, Y Nagai, KP Garrett, TR Wuest… - Blood, The Journal …, 2008 - ashpublications.org
Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors
(TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now …

Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection

TR Wuest, DJJ Carr - The Journal of Immunology, 2008 - journals.aai.org
The chemokine, CXCL10, chemotactic for NK cells, activated T cells, and dendritic cells is
highly expressed during viral infections, including HSV-1. The importance of this chemokine to …

[HTML][HTML] The role of chemokines during herpes simplex virus-1 infection

TR Wuest, DJJ Carr - Frontiers in bioscience: a journal and virtual …, 2008 - ncbi.nlm.nih.gov
Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens.
Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 …

[HTML][HTML] Oxygen tension regulates lysosomal activation and receptor tyrosine kinase degradation

J Hong, TR Wuest, Y Min, PC Lin - Cancers, 2019 - mdpi.com
Oxygen sensing is crucial for adaptation to variable habitats and physiological conditions.
Low oxygen tension, or hypoxia, is a common feature of solid tumors, and hypoxic tumors are …

[HTML][HTML] Neutrophilic granule protein is a novel murine LPS antagonist

J Hong, P Qu, TR Wuest, H Huang, C Huang… - Immune …, 2019 - ncbi.nlm.nih.gov
Neutrophilic granule protein (NGP) was previously reported as a granular protein of neutrophils
in mouse, but the function has not been known clearly. We found the presence of the …

CXCL10 expressing hematopoietic-derived cells are requisite in defense against HSV-1 infection in the nervous system of CXCL10 deficient mice

TR Wuest, M Thapa, M Zheng, DJJ Carr - Journal of neuroimmunology, 2011 - Elsevier
The chemokine CXCL10 is crucial for the control of viral replication through the regulation of
mobilization of antigen-specific T cells to sites of infection. CXCL10 is highly expressed both …

Hypoxia and the Cardiac Lymphatic System

TR Wuest, PC Lin - The Cardiac Lymphatic System: An Overview, 2013 - Springer
Vertebrates are endowed with two separate and complimentary vascular systems. The blood
vasculature serves to deliver nutrients and oxygen, while the lymphatic network acts to …

Herpes Simplex Virus-1 Drives Corneal Lymphangiogenesis via Infected Cell Protein-4 Dependent Expression of VEGF-A

DJ Carr, TR Wuest - Investigative Ophthalmology & Visual …, 2011 - iovs.arvojournals.org
Purpose:: To determine the mechanism (s) by which HSV-1 infection drives VEGF-A up-regulation.
Methods:: Male C57BL/6 (wild type, WT), MyD88 deficient (MyD88-/-), and TRIF …

Radiation and solvent effects on wavelength shifting fibers used with liquid scintillators

…, RA Todd, E Ables, P Armatis, R Bionta… - Radiation Physics and …, 1993 - Elsevier
The chemical compatibility of wave length shifting fibers with several liquid scintillators has
been investigated. Based on systematic characterization of the behavior of the BC-517 family, …