Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be
functionally equivalent to the inner cell mass, which lacks the ability to produce all …

Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Endogenous retroviruses (ERVs) constitute a substantial portion of mammalian genomes,
and their retrotransposition activity helped to drive genetic variation, yet their expression is …

The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Transcriptional enhancers control cell-type–specific gene expression. Primed enhancers
are marked by histone H3 lysine 4 (H3K4) mono/di-methylation (H3K4me1/2). Active …

Retroviruses have been invading mammalian germlines for millions of years, accumulating
in the form of endogenous retroviruses (ERVs) that account for nearly one-tenth of the mouse …

Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES)
cells. Here, we reveal that an essential impact of this process is the protection of cellular …

The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …