User profiles for Todd W. Dowrey
 | Todd DowreyPhD candidate, Boston University Verified email at bu.edu Cited by 87 |
[HTML][HTML] Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity
Background Age-related changes in immune cell composition and functionality are associated
with multimorbidity and mortality. However, many centenarians delay the onset of aging-…
with multimorbidity and mortality. However, many centenarians delay the onset of aging-…
[HTML][HTML] Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment
The human hematopoietic stem cell harbors remarkable regenerative potential that can be
harnessed therapeutically. During early development, hematopoietic stem cells in the fetal …
harnessed therapeutically. During early development, hematopoietic stem cells in the fetal …
[PDF][PDF] Rapid implementation of a SARS-CoV-2 diagnostic quantitative real-time PCR test with emergency use authorization at a large academic safety net hospital
Background Significant delays in the rapid development and distribution of diagnostic
testing for SARS-CoV-2 (COVID-19) infection have prevented adequate public health …
testing for SARS-CoV-2 (COVID-19) infection have prevented adequate public health …
CPHEN‐013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver
Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy and can
give rise to all the mature blood cell types in our body, while at the same time maintaining a …
give rise to all the mature blood cell types in our body, while at the same time maintaining a …
Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors
Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal
tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)–…
tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)–…
[HTML][HTML] qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples
The protocols herein outline the use of qRT-PCR to detect the presence of SARS-CoV-2
genomic RNA in patient samples. In order to cope with potential fluctuations in supply chain and …
genomic RNA in patient samples. In order to cope with potential fluctuations in supply chain and …
A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring
Centenarians provide a unique lens through which to study longevity, healthy aging, and
resiliency. Moreover, models of human aging and resilience to disease that allow for the testing …
resiliency. Moreover, models of human aging and resilience to disease that allow for the testing …
Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential
The human hematopoietic stem cell (HSC) harbors remarkable regenerative potential that
can be harnessed therapeutically. During early development, HSCs in the fetal liver (FL) …
can be harnessed therapeutically. During early development, HSCs in the fetal liver (FL) …
De-novo hematopoiesis from the fetal lung
…, AC Belkina, K Vanuytsel, TW Dowrey… - bioRxiv, 2022 - biorxiv.org
Hemogenic endothelial cells (HECs) are specialized cells that undergo endothelial to
hematopoietic transition (EHT) to give rise to hematopoietic progenitors. Though not defined as a …
hematopoietic transition (EHT) to give rise to hematopoietic progenitors. Though not defined as a …
[HTML][HTML] Transcriptional, Protein-Level and Functional Profiling of Human Fetal Liver (FL)-Derived Hematopoietic Stem Cells (HSCs) at Single Cell Resolution
Intro: The complex and tightly regulated process of human hematopoietic development
culminates in the production of hematopoietic stem cells (HSCs), which subsequently acquire …
culminates in the production of hematopoietic stem cells (HSCs), which subsequently acquire …