Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal
interaction, referred to as topologically associating domains (TADs), interspersed with regions …

Polytene chromosome structure is a characteristic of some polyploid cells where several to
thousands of chromatids are closely associated with perfect alignment of homologous DNA …

The eukaryotic nucleus is both spatially and functionally partitioned. This organization
contributes to the maintenance, expression, and transmission of genetic information. Though our …

Dopaminergic neurotransmission plays a crucial role in the genesis and maintenance of
alcohol dependence. Epigenetic regulation via promoter specific DNA methylation of the …

A major limitation of targeted cancer therapy is the rapid emergence of drug resistance,
which often arises through mutations at or downstream of the drug target or through intrinsic …

Several meiotic processes ensure faithful chromosome segregation to create haploid gametes.
Errors to any one of these processes can lead to zygotic aneuploidy with the potential for …

Condensin complexes play vital roles in chromosome condensation during mitosis and meiosis.
Condensin II uniquely localizes to chromatin throughout the cell cycle and, in addition to …

Structural plasticity in the brain often necessitates dramatic remodeling of neuronal processes,
with attendant reorganization of the cytoskeleton and membranes. Although cytoskeletal …

N-glycanase 1 (NGLY1) Deficiency is a rare monogenic multi-system disorder first described
in 2014. NGLY1 is evolutionarily conserved in model organisms. Here we conducted a …

10.7554/eLife.07068.001 Alterations in Hedgehog (Hh) signaling lead to birth defects and
cancers including medulloblastoma, the most common pediatric brain tumor. Although …