User profiles for Tom L. Blundell
 | Tom L BlundellEmeritus Professor of Biochemistry, University of Cambridge Verified email at cam.ac.uk Cited by 76124 |
Comparative protein modelling by satisfaction of spatial restraints
A Šali, TL Blundell - Journal of molecular biology, 1993 - Elsevier
We describe a comparative protein modelling method designed to find the most probable
structure for a sequence given its alignment with related structures. The three dimensional (3D) …
structure for a sequence given its alignment with related structures. The three dimensional (3D) …
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
Drug development has a high attrition rate, with poor pharmacokinetic and safety properties
a significant hurdle. Computational approaches may help minimize these risks. We have …
a significant hurdle. Computational approaches may help minimize these risks. We have …
FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties
FUGUE, a program for recognizing distant homologues by sequence-structure comparison (http://www-cryst.bioc.cam.ac.uk/fugue/),
has three key features. (1) Improved environment-…
has three key features. (1) Improved environment-…
The TRANSPARENT TESTA GLABRA1 Locus, Which Regulates Trichome Differentiation and Anthocyanin Biosynthesis in Arabidopsis, Encodes a WD40 Repeat …
…, CM James, N Srinivasan, TL Blundell… - The Plant …, 1999 - academic.oup.com
The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and
biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and …
biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and …
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex
…, DS Yu, T Lo, S Anand, MY Lee, TL Blundell… - Nature, 2002 - nature.com
The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase
enzyme, in pathways for DNA repair by homologous recombination. We report here the …
enzyme, in pathways for DNA repair by homologous recombination. We report here the …
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide
range of physiological and pathological activities 1 . Signal transduction requires …
range of physiological and pathological activities 1 . Signal transduction requires …
mCSM: predicting the effects of mutations in proteins using graph-based signatures
Motivation: Mutations play fundamental roles in evolution by introducing diversity into genomes.
Missense mutations in structural genes may become either selectively advantageous or …
Missense mutations in structural genes may become either selectively advantageous or …
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
Cancer genome and other sequencing initiatives are generating extensive data on non-synonymous
single nucleotide polymorphisms (nsSNPs) in human and other genomes. In order …
single nucleotide polymorphisms (nsSNPs) in human and other genomes. In order …
High-throughput crystallography for lead discovery in drug design
TL Blundell, H Jhoti, C Abell - Nature Reviews Drug Discovery, 2002 - nature.com
Abstract Knowledge of the three-dimensional structures of protein targets now emerging from
genomic data has the potential to accelerate drug discovery greatly. X-ray crystallography …
genomic data has the potential to accelerate drug discovery greatly. X-ray crystallography …
HOMSTRAD: a database of protein structure alignments for homologous families
We describe a database of protein structure alignments for homologous families. The database
HOMSTRAD presently contains 130 protein families and 590 aligned structures, which …
HOMSTRAD presently contains 130 protein families and 590 aligned structures, which …