Chromosomes are the physical realization of genetic information and thus form the basis for
its readout and propagation. Here we present a high-resolution chromosomal contact map …

The nucleus is a highly heterogeneous structure, containing various 'landmarks' such as the
nuclear envelope and regions of euchromatin or dense heterochromatin. At a morphological …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

Deciphering the rules of genome folding in the cell nucleus is essential to understand its
functions. Recent chromosome conformation capture (Hi-C) studies have revealed that the …

The discovery of interchromosomal interactions in higher eukaryotes points to a functional
interplay between genome architecture and gene expression, challenging the view of …

Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and
post-replicative DNA repair 1 , 2 . In addition, evidence from model organisms 3 , 4 , 5 , 6 and …

… We introduced the notion of cluster seeds to handle this problem; we refer the reader to
Sexton and others (1985) for the details. … Thomas R. Sexton is associate professor in the …

Studies published between 1983 and 1995 that examined the effectiveness of career
interventions were subjected to a meta-analytic review to replicate LW Oliver and AR Spokane's (…

DEA models treat the DMU as a “black box.” Inputs enter and outputs exit, with no
consideration of the intervening steps. Consequently, it is difficult, if not impossible, to provide …

We show how to use DEA to model DMUs that produce in two stages, with output from the
first stage becoming input to the second stage. Our model allows for any orientation or scale …