In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …

In recent years, carbohydrate epimerases have attracted a lot of attention as efficient biocatalysts
that can convert abundant sugars (eg d-fructose) directly into rare counterparts (eg d-…

In its first 25 years JCAMD has been disseminating a large number of techniques aimed at
finding better medicines faster. These include genetic algorithms, COMFA, QSAR, structure …

Baeyer–Villiger monooxygenases (BVMOs) catalyze the oxidation of ketones to esters or
lactones by using molecular oxygen and a cofactor. Type I BVMOs display a strong preference …

Chiral amines are important building blocks, especially for the pharmaceutical industry.
Although amine transaminases (ATAs) are versatile enzymes to synthesize chiral amines, the …

The Virus-X—Viral Metagenomics for Innovation Value—project was a scientific expedition
to explore and exploit uncharted territory of genetic diversity in extreme natural environments …

To alter the amine donor/acceptor spectrum of an (S)-selective amine transaminase (ATA),
a library based on the Vibrio fluvialis ATA targeting four residues close to the active site (L56, …

Homology and similarity based approaches are most widely used for the identification of new
enzymes for biocatalysis. However, they are not suitable to find truly novel scaffolds with a …

Bacteriophages encode a wide variety of cell wall disrupting enzymes that aid the viral
escape in the final stages of infection. These lytic enzymes have accumulated notable interest …

In order to improve the efficiency of directed evolution experiments, in silico multiple‐substrate
clustering was combined with an analysis of the variability of natural enzymes within a …