In Alzheimer's disease (AD), the distribution of the amyloid precursor protein (APP) and its
fragments other than amyloid beta, has not been fully characterized. Here, we investigate the …

Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid
precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact …

Synaptic degeneration has been reported as one of the best pathological correlates of cognitive
deficits in Alzheimer’s disease. However, the location of these synaptic alterations within …

The use of human post-mortem brain material is of great value when investigating which
pathological mechanisms occur in human brain, and to avoid translational problems which …

Parallel corticostriatonigral circuits have been proposed that separately process motor,
cognitive, and emotional‐motivational information. Functional integration requires that …

In Alzheimer’s disease (AD), a central role is given to the extracellular deposition of Aβ
peptides, remotely produced by the proteolysis of the amyloid precursor protein (APP). This …

The large size of imaging datasets generated by next-generation histology methods limits
the adoption of those approaches in research and the clinic. We propose pAPRica (pipelines …

Alzheimer’s disease (AD) is a progressive neurodegenerative disease which affects 47
million people worldwide, being the most prominent type of dementia. The etiology of the …

La maladie d'Alzheimer (MA) est une maladie neurodégénérative qui touche 47 millions de
personnes dans le monde et représente le type de démence le plus répandu. L'étiologie de …

We propose an end-to-end image analysis pipeline based on the Adaptive Particle Representation
(APR) for analyzing large 3D cleared tissue samples such as whole mouse brains or …