Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties
in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-…

Infarcted hearts are macroscopically stiffer than healthy organs. Nevertheless, although cell
behavior is mediated by the physical features of the cell niche, the intrinsic micromechanical …

Bone marrow-derived mesenchymal stem cells (MSCs) reduce acute lung injury in animals
challenged by bleomycin or bacterial lipopolysaccaride. It is not known, however, whether …

We present a procedure that allows a reliable determination of the elastic (Young’s) modulus
of soft samples, including living cells, by atomic force microscopy (AFM). The standardized …

Bioartificial lungs re-engineered from decellularized organ scaffolds are a promising alternative
to lung transplantation. Critical features for improving scaffold repopulation depend on …

The principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly
is an essential embryonic event in which three tissues coordinate to direct the expansion of …

The lineage commitment of many cultured stem cells, including adult neural stem cells (NSCs),
is strongly sensitive to the stiffness of the underlying extracellular matrix. However, it …

This work describes the development of a three-dimensional (3D) model of osteogenesis
using mouse preosteoblastic MC3T3-E1 cells and a soft synthetic matrix made out of self-…

Cells from lung and other tissues are subjected to forces of opposing directions that are
largely transmitted through integrin-mediated adhesions. How cells respond to force …

Lung bioengineering, a novel approach to obtain organs potentially available for transplantation,
is based on decellularizing donor lungs and seeding natural scaffolds with stem cells. …