We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159
controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Background— Fixed-dose unmonitored treatment with dabigatran etexilate is effective and
has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared …

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-…

In Graves' disease (GD), a combination of genetic, epigenetic and environmental factors
causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations …

Background Recent genome-wide association (GWA) analyses have identified common
single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the …

Dioxin exposure has experimentally been associated with changes in DNA methylation, an
epigenetic change that is associated with disease. The present study aims to investigate if …