[HTML][HTML] Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

…, N Ashman, H Jeffery, J Smith, J Valli, T Becvar… - PLoS …, 2019 - journals.plos.org
The protozoan parasite Leishmania possesses a single flagellum, which is remodelled during
the parasite’s life cycle from a long motile flagellum in promastigote forms in the sand fly to …

[HTML][HTML] Comparative genomics of Leishmania (Mundinia)

…, AY Kostygov, J Sádlová, Y Kleschenko, T Bečvář… - BMC genomics, 2019 - Springer
Background Trypanosomatids of the genus Leishmania are parasites of mammals or reptiles
transmitted by bloodsucking dipterans. Many species of these flagellates cause important …

[HTML][HTML] Experimental transmission of Leishmania (Mundinia) parasites by biting midges (Diptera: Ceratopogonidae)

T Becvar, B Vojtkova, P Siriyasatien, J Votypka… - PLoS …, 2021 - journals.plos.org
Leishmania parasites, causative agents of leishmaniasis, are currently divided into four
subgenera: Leishmania, Viannia, Sauroleishmania and Mundinia. The recently established …

[HTML][HTML] Characterization of a new Leishmania major strain for use in a controlled human infection model

H Ashwin, J Sadlova, B Vojtkova, T Becvar… - Nature …, 2021 - nature.com
Leishmaniasis is widely regarded as a vaccine-preventable disease, but the costs required
to reach pivotal Phase 3 studies and uncertainty about which candidate vaccines should be …

[HTML][HTML] Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: Phosphatidate phosphatase 2-like protein controls cell cycle progression and …

…, ES Gerasimov, T Leštinová, T Bečvář… - PLoS neglected …, 2022 - journals.plos.org
Leishmaniasis is a parasitic vector-borne disease caused by the protistan flagellates of the
genus Leishmania. Leishmania (Viannia) guyanensis is one of the most common causative …

Catalase impairs Leishmania mexicana development and virulence

J Sádlová, L Podešvová, T Bečvář, C Bianchi… - Virulence, 2021 - Taylor & Francis
Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide,
thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene …

[HTML][HTML] Infectiousness of Asymptomatic Meriones shawi, Reservoir Host of Leishmania major

J Sadlova, B Vojtkova, T Lestinova, T Becvar, D Frynta… - Pathogens, 2023 - mdpi.com
Leishmaniases are neglected diseases caused by protozoans of the genus Leishmania that
threaten millions of people worldwide. Cutaneous leishmaniasis (CL) caused by L. major is …

[HTML][HTML] Development of Leishmania (Mundinia) in guinea pigs

T Becvar, P Siriyasatien, P Bates, P Volf, J Sádlová - Parasites & vectors, 2020 - Springer
Background Leishmaniasis is a human and animal disease caused by parasites of the
genus Leishmania, which is now divided into four subgenera, Leishmania, Viannia, …

[HTML][HTML] Porcisia transmission by prediuresis of sand flies

J Sadlova, D Bacikova, T Becvar, B Vojtkova… - Frontiers in cellular …, 2022 - frontiersin.org
Parasites of the genus Porcisia, together with the genus Endotrypanum, form a sister clade
to the species-rich and medically important genus Leishmania. Both Porcisia species, P. …

[HTML][HTML] Host competence of African rodents Arvicanthis neumanni, A. niloticus and Mastomys natalensis for Leishmania major

…, K Hrncirova, T Lestinova, T Spitzova, T Becvar… - International Journal for …, 2019 - Elsevier
Cutaneous leishmaniasis caused by Leishmania major is a typical zoonosis circulating in
rodents. In Sub-Saharan Africa the reservoirs remain to be identified, although L. major has …