β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

Wnt–β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium
by promoting stem cell renewal 1 , 2 . In the small intestine, epithelial Paneth cells secrete …

Targeting of Wnt signaling represents a promising anti-cancer therapy. However, the
consequences of systemically attenuating the Wnt pathway in an adult organism are unknown. Here…

In the past decade, single-cell transcriptomics has helped to uncover new cell types and
states and led to the construction of a cellular compendium of health and disease. Despite this …

Curcuma is a world-renowned herb known for its immense health benefits. In this study,
physicochemical analyses were performed on the curcumin standard sample and curcumin …

There was studied dough made from refined white and brown wheat flours of different
granulometry by means of mechanical, thermal analysis and rheological testing. Observed results …

Aims Myocardial fibrosis critically contributes to cardiac dysfunction in inflammatory dilated
cardiomyopathy (iDCM). Activation of transforming growth factor-β (TGF-β) signalling is a key-…

β-Catenin, apart from playing a cell-adhesive role, is a key nuclear effector of Wnt signaling.
Based on activity assays in Drosophila, we generated mouse strains where the endogenous …

Members of the Tcf/Lef family of the HMG box transcription factors are nuclear effectors of
the Wnt signal transduction pathway. Upon Wnt signaling, TCF/LEF proteins interact with β‐…

Despite recent progress in recognizing the importance of mesenchymal cells for the
homeostasis of the intestinal system, the current picture of how these cells communicate with the …