The metabolism of oxygen, although central to life, produces reactive oxygen species (ROS)
that have been implicated in processes as diverse as cancer, cardiovascular disease and …

Methods for genomic analysis at single-cell resolution enable new understanding of
complex biological phenomena. Single-cell techniques, ranging from flow cytometry and …

Studying complex biological systems such as a developing embryo, a tumor, or a microbial
ecosystem often involves understanding the behavior and heterogeneity of the individual …

Cancer is often viewed as a caricature of normal developmental processes, but the extent to
which its cellular heterogeneity truly recapitulates multilineage differentiation processes of …

Interest in single-cell whole-transcriptome analysis is growing rapidly, especially for profiling
rare or heterogeneous populations of cells. We compared commercially available single-…

Background The identification of high-risk stage II colon cancers is key to the selection of
patients who require adjuvant treatment after surgery. Microarray-based multigene-expression …

We study the behavior of epidemic spreading in networks, and, in particular, scale free
networks. We use the Susceptible-Infected-Removed (SIR) epidemiological model. We give …

BACKGROUND & AIMS: Paneth cells contribute to the small intestinal niche of Lgr5 + stem
cells. Although the colon also contains Lgr5 + stem cells, it does not contain Paneth cells. We …

Single-cell quantitative real-time PCR (qRT-PCR) combined with high-throughput arrays
allows the analysis of gene expression profiles at a molecular level in approximately 11 h after …

It has been postulated that there is a link between inflammation and cancer. Here we
describe a role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory …