[PDF][PDF] The interferon landscape along the respiratory tract impacts the severity of COVID-19

…, L Marongiu, FA Facchini, A Bottazzi, T Fossali… - Cell, 2021 - cell.com
Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune
mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families …

Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy

…, L Milazzo, L Oreni, G Bestetti, T Fossali… - European journal of …, 2020 - Elsevier
Background Tocilizumab, a humanized monoclonal antibody, targets IL-6 receptors blocking
downstream pro-inflammatory effects of IL-6. In preliminary reports it was suggested to be …

Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?

…, C Tedesco, P Maccagni, T Fossali… - Critical care …, 2005 - journals.lww.com
Objective: To investigate if prone position delays the progression of experimental ventilator-induced
lung injury, possibly due to a more homogeneous distribution of strain within lung …

[HTML][HTML] Lactate as a marker of energy failure in critically ill patients: hypothesis

F Valenza, G Aletti, T Fossali, G Chevallard, F Sacconi… - Critical Care, 2005 - Springer
Lactate measurement in the critically ill has been traditionally used to stratify patients with
poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of …

Effects of prone position on lung recruitment and ventilation-perfusion matching in patients with COVID-19 acute respiratory distress syndrome: a combined CT scan …

T Fossali, B Pavlovsky, D Ottolina, R Colombo… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: Prone positioning allows to improve oxygenation and decrease mortality rate
in COVID-19–associated acute respiratory distress syndrome (C-ARDS). However, the …

[HTML][HTML] Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome

L Pandolfi, T Fossali, V Frangipane, S Bozzini… - BMC pulmonary …, 2020 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly reached
pandemic proportions. Given that the main target of SARS-CoV-2 are lungs leading to …

Management of mechanical ventilation during laparoscopic surgery

F Valenza, G Chevallard, T Fossali, V Salice… - Best Practice & …, 2010 - Elsevier
Laparoscopy is widely used in the surgical treatment of a number of diseases. Its advantages
are generally believed to lie on its minimal invasiveness, better cosmetic outcome and …

[HTML][HTML] Invasive pulmonary aspergillosis complicating SARS-CoV-2 pneumonia: a diagnostic challenge

…, A Castelli, E Angeli, T Fossali… - Travel medicine and …, 2020 - ncbi.nlm.nih.gov
A 73-year old Italian man with a history of diabetes, hypertension, hyperthyroidism, atrial
fibrillation and obesity was transferred to our hospital on March 1, 2020 due to pneumonia …

[HTML][HTML] Neutrophil extracellular traps induce the epithelial-mesenchymal transition: implications in post-COVID-19 fibrosis

…, M De Amici, M Nebuloni, T Fossali… - Frontiers in …, 2021 - frontiersin.org
The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids
pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 …

Association between left ventricular outflow tract opening and successful resuscitation after cardiac arrest

E Catena, D Ottolina, T Fossali, R Rech, B Borghi… - Resuscitation, 2019 - Elsevier
Background Survival after cardiac arrest depends on adequate cardiopulmonary resuscitation
(CPR). Manual or mechanical external chest compression may be ineffective to restore …