Hair cell death is a major cause of hearing impairment. Preservation of surface barrier upon
hair cell loss is critical to prevent leakage of potassium-rich endolymph into the organ of …

Hair cells of the organ of Corti (OC) of the cochlea exhibit distinct planar polarity, both at the
tissue and cellular level. Planar polarity at tissue level is manifested as uniform orientation of …

Cdc42 regulates the initial establishment of cytoskeletal and junctional structures, but only
little is known about its role at later stages of cellular differentiation. We studied Cdc42′s role …

Human generated environmental change profoundly affects organisms that reside across
diverse ecosystems. Although nervous systems evolved to flexibly sense, respond, and adapt …

Prevention of auditory hair cell death offers therapeutic potential to rescue hearing.
Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with …

Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea
and convey sound information to the brain via synapses with the auditory nerve. IHCs have …

Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise
as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown …

Wound healing in the inner ear sensory epithelia is performed by the apical domains of
supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become …

Rakennusvaiheita käsitellään koneenkuljettajan näkökulmasta. Aineisto perustuu kirjoittajien
pitkäaikaisiin käytännön kokemuksiin ja näkemyksiin metsäteiden rakentamisesta. …

Mechanosensory hair cells of the cochlea are the principal receptor cells of hearing. As these
cells cannot be replaced in mammals, developmental defects in and death of these cells …