Spinogenesis and synaptic pruning during development are widely believed to subserve
connectional specificity in the mature CNS via Hebbian-type reinforcement. Refinement of …

Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and
gene expression changes. Early intervention during childhood is thought to benefit prognosis. …

Abnormalities in the processes of the generation and/or pruning of dendritic spines have
been implicated in several mental disorders including autism and schizophrenia. We have …

In autism spectrum disorder (ASD), disrupted functional and structural connectivity in the
social brain has been suggested as the core biological mechanism underlying the social …

Pyramidal cells in the primate cerebral cortex, particularly those in layer III, exhibit regional
variation in both the time course and magnitude of postnatal growth and pruning of dendrites …

Neocortical pyramidal cells are characterized by markedly different structure among cortical
areas in the mature brain. In the ventral visual pathway of adult primates, pyramidal cells …

In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to
infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these …

The synapse number and the related dendritic spine number in the cerebral cortex of
primates shows a rapid increase after birth. Depending on the brain region and species, the …

Recently we demonstrated that neocortical pyramidal cells in visual, visual association and
prefrontal cortex of the macaque monkey are characterised by different growth, branching, …

Pyramidal cells grow and mature at different rates among different cortical areas in the
macaque monkey. In particular, differences across the areas have been reported in both the …