Crystal structure of the channelrhodopsin light-gated cation channel
Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have
shown experimental utility in optogenetics; for example, neurons expressing ChRs can be …
shown experimental utility in optogenetics; for example, neurons expressing ChRs can be …
A three-dimensional movie of structural changes in bacteriorhodopsin
…, D Im, T Fujiwara, Y Yamanaka, B Jeon, T Nishizawa… - Science, 2016 - science.org
Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport protein.
We used time-resolved serial femtosecond crystallography at an x-ray free electron laser …
We used time-resolved serial femtosecond crystallography at an x-ray free electron laser …
Structure and function of Zucchini endoribonuclease in piRNA biogenesis
…, L Bonnefond, N Matsumoto, T Nishizawa… - Nature, 2012 - nature.com
PIWI-interacting RNAs (piRNAs) silence transposons to maintain genome integrity in animal
germ lines 1 , 2 , 3 , 4 . piRNAs are classified as primary and secondary piRNAs, depending …
germ lines 1 , 2 , 3 , 4 . piRNAs are classified as primary and secondary piRNAs, depending …
Crystal structure of a claudin provides insight into the architecture of tight junctions
Tight junctions are cell-cell adhesion structures in epithelial cell sheets that surround organ
compartments in multicellular organisms and regulate the permeation of ions through the …
compartments in multicellular organisms and regulate the permeation of ions through the …
Structural basis for Na+ transport mechanism by a light-driven Na+ pump
Krokinobacter eikastus rhodopsin 2 (KR2) is the first light-driven Na + pump discovered,
and is viewed as a potential next-generation optogenetics tool. Since the positively charged …
and is viewed as a potential next-generation optogenetics tool. Since the positively charged …
[PDF][PDF] Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex
K Kato, W Zhou, S Okazaki, Y Isayama, T Nishizawa… - Cell, 2022 - cell.com
The type III-E CRISPR-Cas effector Cas7-11, with dual RNase activities for precursor CRISPR
RNA (pre-crRNA) processing and crRNA-guided target RNA cleavage, is a new platform …
RNA (pre-crRNA) processing and crRNA-guided target RNA cleavage, is a new platform …
[HTML][HTML] Structural insights into tetraspanin CD9 function
…, N Nomura, K Sato, M Ikawa, T Nishizawa… - Nature …, 2020 - nature.com
Tetraspanins play critical roles in various physiological processes, ranging from cell
adhesion to virus infection. The members of the tetraspanin family have four membrane-spanning …
adhesion to virus infection. The members of the tetraspanin family have four membrane-spanning …
Activation mechanism of endothelin ETB receptor by endothelin-1
Endothelin, a 21-amino-acid peptide, participates in various physiological processes, such
as regulation of vascular tone, humoral homeostasis, neural crest cell development and …
as regulation of vascular tone, humoral homeostasis, neural crest cell development and …
[PDF][PDF] Structure of the miniature type VF CRISPR-Cas effector enzyme
…, H Hirano, K Kobayashi, T Kusakizako, T Nishizawa… - Molecular Cell, 2021 - cell.com
RNA-guided DNA endonucleases derived from CRISPR-Cas adaptive immune systems are
widely used as powerful genome-engineering tools. Among the diverse CRISPR-Cas …
widely used as powerful genome-engineering tools. Among the diverse CRISPR-Cas …
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
M Hiraizumi, K Yamashita, T Nishizawa, O Nureki - Science, 2019 - science.org
In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …