User profiles for Tomoko Ohyama
Tomoko OhyamaAssistant Professor (Jan 2017-) Verified email at mcgill.ca Cited by 3328 |
A multilevel multimodal circuit enhances action selection in Drosophila
Natural events present multiple types of sensory cues, each detected by a specialized sensory
modality. Combining information from several modalities is essential for the selection of …
modality. Combining information from several modalities is essential for the selection of …
Labeling of active neural circuits in vivo with designed calcium integrators
The identification of active neurons and circuits in vivo is a fundamental challenge in understanding
the neural basis of behavior. Genetically encoded calcium (Ca 2+ ) indicators (GECIs…
the neural basis of behavior. Genetically encoded calcium (Ca 2+ ) indicators (GECIs…
Discovery of brainwide neural-behavioral maps via multiscale unsupervised structure learning
A single nervous system can generate many distinct motor patterns. Identifying which neurons
and circuits control which behaviors has been a laborious piecemeal process, usually for …
and circuits control which behaviors has been a laborious piecemeal process, usually for …
Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations
K Inoue, M Khajavi, T Ohyama, S Hirabayashi… - Nature …, 2004 - nature.com
The molecular mechanisms by which different mutations in the same gene can result in
distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause …
distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause …
Recurrent architecture for adaptive regulation of learning in the insect brain
Dopaminergic neurons (DANs) drive learning across the animal kingdom, but the upstream
circuits that regulate their activity and thereby learning remain poorly understood. We …
circuits that regulate their activity and thereby learning remain poorly understood. We …
[HTML][HTML] A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis
Synaptic vesicle (SV) exo- and endocytosis are tightly coupled to sustain neurotransmission
in presynaptic terminals, and both are regulated by Ca 2+ . Ca 2+ influx triggered by voltage-…
in presynaptic terminals, and both are regulated by Ca 2+ . Ca 2+ influx triggered by voltage-…
[HTML][HTML] High-Throughput Analysis of Stimulus-Evoked Behaviors in Drosophila Larva Reveals Multiple Modality-Specific Escape Strategies
All organisms react to noxious and mechanical stimuli but we still lack a complete
understanding of cellular and molecular mechanisms by which somatosensory information is …
understanding of cellular and molecular mechanisms by which somatosensory information is …
[PDF][PDF] Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero …
M Khajavi, K Inoue, W Wiszniewski, T Ohyama… - The American Journal of …, 2005 - cell.com
Mutations in MPZ, the gene encoding myelin protein zero (MPZ), the major protein
constituent of peripheral myelin, can cause the adult-onset, inherited neuropathy Charcot-Marie-Tooth …
constituent of peripheral myelin, can cause the adult-onset, inherited neuropathy Charcot-Marie-Tooth …
[PDF][PDF] Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling
P Verstreken, T Ohyama, C Haueter, RLP Habets… - Neuron, 2009 - cell.com
Synaptic vesicle endocytosis is critical for maintaining synaptic communication during intense
stimulation. Here we describe Tweek, a conserved protein that is required for synaptic …
stimulation. Here we describe Tweek, a conserved protein that is required for synaptic …
FM 1-43 Labeling of Synaptic Vesicle Pools at the Drosophila Neuromuscular Junction
To maintain transmitter release during intense stimulation, neurons need to efficiently recycle
vesicles at the synapse. Following membrane fusion, vesicles are reshaped and formed …
vesicles at the synapse. Following membrane fusion, vesicles are reshaped and formed …