User profiles for Tomoko Ohyama

Tomoko Ohyama

Assistant Professor (Jan 2017-)
Verified email at mcgill.ca
Cited by 3328

A multilevel multimodal circuit enhances action selection in Drosophila

T Ohyama, CM Schneider-Mizell, RD Fetter, JV Aleman… - Nature, 2015 - nature.com
Natural events present multiple types of sensory cues, each detected by a specialized sensory
modality. Combining information from several modalities is essential for the selection of …

Labeling of active neural circuits in vivo with designed calcium integrators

BF Fosque, Y Sun, H Dana, CT Yang, T Ohyama… - Science, 2015 - science.org
The identification of active neurons and circuits in vivo is a fundamental challenge in understanding
the neural basis of behavior. Genetically encoded calcium (Ca 2+ ) indicators (GECIs…

Discovery of brainwide neural-behavioral maps via multiscale unsupervised structure learning

JT Vogelstein, Y Park, T Ohyama, RA Kerr, JW Truman… - Science, 2014 - science.org
A single nervous system can generate many distinct motor patterns. Identifying which neurons
and circuits control which behaviors has been a laborious piecemeal process, usually for …

Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations

K Inoue, M Khajavi, T Ohyama, S Hirabayashi… - Nature …, 2004 - nature.com
The molecular mechanisms by which different mutations in the same gene can result in
distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause …

Recurrent architecture for adaptive regulation of learning in the insect brain

…, R Arruda, K Eichler, J Valdes-Aleman, T Ohyama… - Nature …, 2020 - nature.com
Dopaminergic neurons (DANs) drive learning across the animal kingdom, but the upstream
circuits that regulate their activity and thereby learning remain poorly understood. We …

[HTML][HTML] A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis

CK Yao, YQ Lin, CV Ly, T Ohyama, CM Haueter… - Cell, 2009 - cell.com
Synaptic vesicle (SV) exo- and endocytosis are tightly coupled to sustain neurotransmission
in presynaptic terminals, and both are regulated by Ca 2+ . Ca 2+ influx triggered by voltage-…

[HTML][HTML] High-Throughput Analysis of Stimulus-Evoked Behaviors in Drosophila Larva Reveals Multiple Modality-Specific Escape Strategies

T Ohyama, T Jovanic, G Denisov, TC Dang… - PloS one, 2013 - journals.plos.org
All organisms react to noxious and mechanical stimuli but we still lack a complete
understanding of cellular and molecular mechanisms by which somatosensory information is …

[PDF][PDF] Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero …

M Khajavi, K Inoue, W Wiszniewski, T Ohyama… - The American Journal of …, 2005 - cell.com
Mutations in MPZ, the gene encoding myelin protein zero (MPZ), the major protein
constituent of peripheral myelin, can cause the adult-onset, inherited neuropathy Charcot-Marie-Tooth …

[PDF][PDF] Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling

P Verstreken, T Ohyama, C Haueter, RLP Habets… - Neuron, 2009 - cell.com
Synaptic vesicle endocytosis is critical for maintaining synaptic communication during intense
stimulation. Here we describe Tweek, a conserved protein that is required for synaptic …

FM 1-43 Labeling of Synaptic Vesicle Pools at the Drosophila Neuromuscular Junction

P Verstreken, T Ohyama, HJ Bellen - Exocytosis and Endocytosis, 2008 - Springer
To maintain transmitter release during intense stimulation, neurons need to efficiently recycle
vesicles at the synapse. Following membrane fusion, vesicles are reshaped and formed …