Toll-like receptor (TLR) responses are regulated to avoid toxicity and achieve coordinated
responses appropriate for the cell environment. We found that Notch and TLR pathways …

This study aimed to clarify the characteristics of rat vocal fold scarring by examining the
alteration of key components in the extracellular matrix: hyaluronic acid, collagen, and fibronectin…

Mechanosensory hair cells and supporting cells develop from common precursors located
in the prosensory domain of the developing cochlear epithelium. Prosensory cell …

Notch-mediated lateral inhibition has been reported to regulate auditory hair cell and supporting
cell development from common precursors. While the Notch effector genes Hes1, Hes5 …

Objectives: We used an acute vocal fold injury in a rat model to characterize vocal fold wound
healing by studying the expression pattern of the extracellular matrix components in the …

Objectives: Vocal fold scarring is the major cause of voice disorders after voice surgery or
laryngeal trauma. The role of inflammatory factors in vocal fold wound healing and fibrosis has …

Aged vocal folds have been reported to have dense collagen deposition and decreased
hyaluronic acid (HA) in the lamina propria. These characteristics are thought to contribute to …

A notable example of spiral architecture in organs is the mammalian cochlear duct, where
the morphology is critical for hearing function. Genetic studies have revealed necessary …

During cochlear development, hair cells (HCs) and supporting cells differentiate in the
prosensory domain to form the organ of Corti, but how one row of inner HCs (IHCs) and three …

Objectives: Fibroblasts are reported to play an important role in producing the extracellular
matrix of the vocal fold. However, no reports have focused on how and where these cells are …