Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs)
in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …

Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the
mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 …

Recent studies have established important roles of de novo mutations (DNMs) in autism
spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin …

Context Various factors are involved in the pathogenesis of schizophrenia. Accumulation of
advanced glycation end products, including pentosidine, results from carbonyl stress, a state …

The calcineurin cascade is central to neuronal signal transduction, and genes in this network
are intriguing candidate schizophrenia susceptibility genes. To replicate and extend our …

Background Mitochondrial dysfunction (MtD) has been observed in approximately five
percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-…

Neurotrophic factors (NFs) play a pivotal role in the development of the central nervous system.
They are thus also suspected of being involved in the etiology of schizophrenia. Previous …

Genome-wide association studies (GWASs) have identified >100 susceptibility loci for
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous …

Purpose Epidemiologic studies have shown that the incidence of epilepsy is the highest in
the elderly population. Because the elderly constitutes the most rapidly growing population, …

BACKGROUND: Sialyltransferase 8B (SIAT8B) and 8D (SIAT8D) are two polysialyltransferases
that catalyze the transfer of polysialic acid (PSA) to the neural cell adhesion molecule 1 (…