User profiles for Tomonori Hosoya
Tomonori HosoyaVerified email at umich.edu Cited by 2994 |
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
Emphysema is one of the major pathological abnormalities associated with chronic obstructive
pulmonary disease. The protease/antiprotease imbalance and inflammation resulting …
pulmonary disease. The protease/antiprotease imbalance and inflammation resulting …
[HTML][HTML] Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
The Nrf2-Keap1 system coordinately regulates cytoprotective gene expression via the
antioxidant responsive element (ARE). The expression of several ARE-regulated genes was …
antioxidant responsive element (ARE). The expression of several ARE-regulated genes was …
BRG1 Interacts with Nrf2 To Selectively Mediate HO-1 Induction in Response to Oxidative Stress
J Zhang, T Ohta, A Maruyama, T Hosoya… - … and cellular biology, 2006 - Taylor & Francis
NF-E2-related factor 2 (Nrf2) regulates antioxidant-responsive element-mediated induction
of cytoprotective genes in response to oxidative stress. The purpose of this study was to …
of cytoprotective genes in response to oxidative stress. The purpose of this study was to …
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
…, A Maruyama, A Yoshida, K Tazumi, T Hosoya… - Archives of biochemistry …, 2011 - Elsevier
Iron is an essential element of hemoglobin, and efficient iron recycling from senescent
erythrocytes by splenic macrophages is required for erythrocyte hemoglobin synthesis during …
erythrocytes by splenic macrophages is required for erythrocyte hemoglobin synthesis during …
Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions
…, F Katsuoka, S Noda, J Mimura, T Hosoya… - … and cellular biology, 2005 - Am Soc Microbiol
Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has
been suggested to provoke inflammatory and/or allergic disorders, including asthma, rhinitis, …
been suggested to provoke inflammatory and/or allergic disorders, including asthma, rhinitis, …
GATA-3 is required for early T lineage progenitor development
T Hosoya, T Kuroha, T Moriguchi… - Journal of Experimental …, 2009 - rupress.org
Most T lymphocytes appear to arise from very rare early T lineage progenitors (ETPs) in the
thymus, but the transcriptional programs that specify ETP generation are not completely …
thymus, but the transcriptional programs that specify ETP generation are not completely …
[HTML][HTML] Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning
The transcription factor GATA-2 plays vital roles in quite diverse developmental programs,
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified a …
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified a …
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
T Moriguchi, H Motohashi, T Hosoya… - Proceedings of the …, 2003 - National Acad Sciences
There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities.
A critical question in risk assessment of dioxin and related compounds is whether humans …
A critical question in risk assessment of dioxin and related compounds is whether humans …
From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation
GATA family transcription factors play multiple vital roles in hematopoiesis in many cell lineages,
and in particular, T cells require GATA‐3 for execution of several developmental steps. …
and in particular, T cells require GATA‐3 for execution of several developmental steps. …
GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long
generation of blood cells. Approximately 75% of cells in a highly enriched long-term …
generation of blood cells. Approximately 75% of cells in a highly enriched long-term …