[HTML][HTML] Switch between large hand-over-hand and small inchworm-like steps in myosin VI

…, I Arimoto, K Ikezaki, M Sugawa, H Ueno, T Komori… - Cell, 2010 - cell.com
Many biological motor molecules move within cells using stepsizes predictable from their
structures. Myosin VI, however, has much larger and more broadly distributed stepsizes than …

Real‐time observation of flexible domain movements in CRISPR–Cas9

S Osuka, K Isomura, S Kajimoto, T Komori… - The EMBO …, 2018 - embopress.org
The CRISPR ‐associated protein Cas9 is widely used for genome editing because it cleaves
target DNA through the assistance of a single‐guide RNA (sg RNA ). Structural studies …

[HTML][HTML] Crystal structures of the TRIC trimeric intracellular cation channel orthologues

…, Y Nakada-Nakura, S Iwata, K Tsukada, T Komori… - Cell research, 2016 - nature.com
Ca 2+ release from the sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) is
crucial for muscle contraction, cell growth, apoptosis, learning and memory. The trimeric …

[HTML][HTML] The extracellular loop of pendrin and prestin modulates their voltage-sensing property

…, K Wasano, S Takahashi, J Bodner, T Komori… - Journal of Biological …, 2018 - ASBMB
Pendrin and prestin belong to the solute carrier 26 (SLC26) family of anion transporters.
Prestin is unique among the SLC26 family members in that it displays voltage-driven motor …

Site-directed spin labeling electron paramagnetic resonance study of the calcium-induced structural transition in the N-domain of human cardiac troponin C …

S Ueki, M Nakamura, T Komori, T Arata - Biochemistry, 2005 - ACS Publications
Calcium-induced structural transition in the amino-terminal domain of troponin C (TnC) triggers
skeletal and cardiac muscle contraction. The salient feature of this structural transition is …

[HTML][HTML] Simultaneous measurement of nucleotide occupancy and mechanical displacement in myosin-V, a processive molecular motor

T Komori, S Nishikawa, T Ariga, AH Iwane… - Biophysical Journal, 2009 - cell.com
Adenosine triphosphate (ATP) turnover drives various processive molecular motors and
adenosine diphosphate (ADP) release is a principal transition in this cycle. Biochemical and …

Simultaneous observation of the lever arm and head explains myosin VI dual function

K Ikezaki, T Komori, M Sugawa, Y Arai, S Nishikawa… - Small, 2012 - Wiley Online Library
Myosin VI is an adenosine triphosphate (ATP)‐driven dimeric molecular motor that has dual
function as a vesicle transporter and a cytoskeletal anchor. Recently, it was reported that …

[HTML][HTML] G146V mutation at the hinge region of actin reveals a myosin class-specific requirement of actin conformations for motility

TQP Noguchi, T Komori, N Umeki, N Demizu… - Journal of Biological …, 2012 - ASBMB
The G146V mutation in actin is dominant lethal in yeast. G146V actin filaments bind cofilin
only minimally, presumably because cofilin binding requires the large and small actin …

[PDF][PDF] A polysaccharide-based container transportation system powered by molecular motors

Y Tsuchiya, T Komori, M Hirano, T Shiraki… - Angewandte …, 2010 - academia.edu
In living cells, the motor protein myosin, which is driven by ATP hydrolysis, intracellularly
transports cargo such as vesicles and organelles [1, 2] by moving along actin filaments. There …

Measurement system for simultaneous observation of myosin V chemical and mechanical events

T Komori, S Nishikawa, T Ariga, AH Iwane, T Yanagida - Biosystems, 2008 - Elsevier
Myosin V is an actin-based processive molecular motor driven by the chemical energy of
ATP hydrolysis. Although the chemo-mechanical coupling in processive movement has been …